The effect of eight weeks of taurine supplementation on the amount of myostatin, fasting glucose, and insulin resistance in soleus muscle tissue in male rats with type 2 diabetes

Background: Type 2 diabetes is the most common endocrine disease in the world. Recently, it has been shown that the amino acid taurine can be effective in diabetes. The aim of this study was to evaluate the effect of eight weeks of taurine supplementation on myostatin, fasting glucose, and insulin resistance in soleus muscle tissue of male rats with type 2 diabetes. Materials and methods: In this experimental study, 24 male Wistar rats weighing 215 to 230 g were randomly divided into three groups: healthy control, diabetic control, and diabetic taurine. High Fat Diet- Streptozotocin (HFD-STZ) method was used to induce type 2 diabetes. A dosage of 250 mg of taurine per kg of body weight was used in the diabetic taurine group. One-way analysis of variance was used in the research. Results: The results showed that the amount of myostatin, fasting glucose, and insulin resistance were significantly different between healthy control and diabetic control (p=0.001), but in the diabetic group, taurine was not significantly different from the healthy control group. However, there was a significant difference in the amount of research variables with the diabetic control group (p=0.001). Conclusion: It can be concluded that the taurine supplementation can be effective in reducing complications in patients with type 2 diabetes.